Biodegradable polyesters and polyanhydrides for advanced applications

Anotace

This work is focused on preparation and characterization of novel types of biodegradable polyesters and polyanhydrides. Besides the summary of the state of art in the field of biodegradable polymers, a detailed description of biodegradable polylactic acid-polyethylene glycol copolymers preparation is presented, including their applicability on encapsulation technologies. Further part of this work is dedicated to optimization of poly (sebacic anhydride) synthesis. Third part deals with preparation and characterization of polyester urethanes based on polylactic acid and polyethylene glycol linked with biocompatible diisocyanate derived from an amino acid – lysine. Degradation behaviour description of the prepared polymers is integral part of this thesis. Potential application of the compounds can be found in the fields where controlled release of bioactive compounds is required.